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Maria Yu. Obolens'ka
Professor, Dr. Sci. (Mol. Biol.)
Tel: (380-44) 526-31-39;
Fax: (380-44) 526-07-59;
E-mail: m_obolenska@gmail.com
Research Areas:
Bioinformatics:
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Whole genome search for target genes of transcription factors
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Reconstruction of gene regulatory networks
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Modeling of metabolic pathways
Gene expression and its regulation in eukaryotic cells
Folate-related metabolism of one-carbon units
Current research activities:
Systemic analysis of non-canonical functions of interferon alpha:
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In silico genome-wide search for target genes of interferon alpha
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Time-scale experiments on gene expression profiling in rat hepatocytes treated with interferon alpha (oligonucleotide microarray)
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Interrelation between ligand and receptor – evidence from interferon alpha and expression of its receptor
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Study of pathways of intracellular signal transmission from interferon alpha
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Analysis of molecular background for side-effects of interferon alpha from central nervous system
Gene expression in the course of liver cells transition from quiescence to proliferation in regenerating rat liver:
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Expression of interferon alpha target genes in the course of liver regeneration
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Functioning of 2′,5′-oligo(A)synthetase–RNAse L system in the absence of viral damage and its role in the change in the program of cells
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Regulation of interferon alpha target genes at post-transcriptional level
Reconstruction of gene regulatory network:
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Elaboration of algorithms for reconstruction of gene regulatory network
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Development of ensemble method with high grade of parallelization for the gene regulatory network modeling in Grid-environment
Folate-related metabolism of one-carbon units in human placenta in health and disease
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The modeling of physiologically relevant and impaired folate-related metabolism in human placenta
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Investigation of the impact of pathologically relevant concentrations of homocysteine on amino acids metabolism, proliferation and apoptosis in human placenta
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Expression of genes, coding enzymes of folate-related metabolism in human placenta in the course of healthy and preeclamptic pregnancies
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Elaboration of ex vivo system (placenta explants) for the investigation of the effect of different factors on organism functioning
